In contrast with mouse thymocytes, mouse ES cells comprise increased levels of total genomic H3K4me3 and have greater H3K4me3 occupancy on the promoter of the pluripotent gene Oct4 46 In settlement with this, global decreases in H3K4me3 ranges happen throughout retinoic acid (RA)-induced differentiation of mouse ES cells 47 In addition, there are dynamic adjustments in H3K4me3 profiles at specific units of genes throughout ES cell differentiation.

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